Morning Joe economic analyst Steve Rattner and economist John Friedman react to new jobless claims. Aired on 05/07/2020.
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Steve Rattner: Income Inequality Factors Into Unemployment Crisis | Morning Joe | MSNBC
Donald J Trump is now the leading cause of death in America……..let that sink in
What a moronic statement.
Yeah…..keep blaming him…while your Dementia affected hero sits in his basement cave….leading from the front 😉
@brian gardner: Mike Pompeii; was caught in a lie it wasn’t lab created or made by Man; have you, ever read the Bible it speaks of Plagues Famines Earthquakes we are living in the end time’s
@Jon Burrows i killed Republicans today with virus ha ha
@Domino Ryan fake news.
Trump will sacrifice more to win
Richard Bailey HE’ll absolutely sacrifice human lives to win! https://www.healthline.com/health/malignant-narcissism
The orange cockroach and his corrupt maggots, need to go.
@Blake Nicol spoken like a true panty wearing Beta boy. Well done.
Kevin Phillips Dammit. I thought you might be an individual who could partake in some droll, witty sport. I’m slightly bored and wanted some vaguely intelligent back and forth. I was so wrong. Is that the best you’ve got?!! Oh well I’ll leave it there, with your attempted comeback. Btw, I am panty wearing coz I’m a girl.
Blake Nicol, You’re right, I thought he’d be better at a game of witty banter, but yet all he did was call me Kathy, instead of Kathleen, I was so wounded. What do we expect from another Trump bobble head.
Kathleen Jacobson Ikr. Very weak and evidently not very bright. Lol.
@Blake Nicol My corner is throwing in the towel. I have no chance whatsoever debating 2 cat ladies. Peace, love, and waterbeds baby. Namaste.
trump, making America his seventh bankruptcy
Haha, just another one to add to the resume.
Billy Ray
Hope your friends in the top 1% help out by anding back some of their unneeded wealth.
I think not sucker. Go get your trump university degree and fox off.
Those LARGE bailed out companies WILL take over the smaller failing companies.
You know like a government financed leveraged buy out. FREE MARKET, NO
FLUSH THE WASHINGTON TOLIET. VOTE FOR A CHANGE.
@Christian Xander James He has no friend anywhere! He probably lives in his mother’s basement!
@Billy Ray And what do read, chump??
Obama’s economy aside, this is the economy a lying thieving man in charge is only capable of.
De Lores Hollis I do have to say that I was NOT happy, as a Democrat, when Obama and his administration bailed out Wall Street. Under Clinton, and Obama, the Democratic Party became a very exclusive party, and not an inclusive party.
Shawna Weesner
Sadly true. But nothing as bad as the corruption we see now. Pity Bernie is out.
Good luck in this environment.
@Shawna Weesner Then you shouldn’t at all be happy with Trump giving billions to the richest people in the country because they happen to donate to his greed
@Shawna Weesner Go ahead. let the perfect be the enemy of the good.
Moaning about the things that have to be done politically to gain power in a screwed up country like you have in the USA is a fatuous pursuit.
Shawna Weesner without Obama bailing out Wall Street you would have gone into a recession worse than the Great Depression. He had to keep the big banks afloat to ensure the economy ticked over bearing in mind that they were the cause of the crisis in the first place. This time round you have no fall back policy your GDP was down by over 4% in the last quarter which only had 1 month of the Corona Virus impact would hate to see what your GDP will be for this quarter.
“We’re going to win so much, you’re going to be so sick and tired of winning.” Donald Trump said during the 2016 presidential campaign.
Lol he controls mother nature?
@William Bonny Obama was warned and did nothing so basically he murderd those people….
@long nose no that’s the Asian
Hornets job
Hcq studies. Please read and share. https://docs.google.com/document/d/1545C_dJWMIAgqeLEsfo2U8Kq5WprDuARXrJl6N1aDjY/edit
25% unemployment, 30% GDP decline, 80K (probably 200K by fall) deaths… Trump does have the biggest numbers, numbers no one has ever heard of. It’s time to add one more person to the unemployed… Trump.
Thanks, Republicans! Sure glad you gave that MASSIVE tax cut to the 1% in 2017! That’s really helping the economy, just like you said it would!
Something to consider as far as the death toll… https://www.psychologytoday.com/us/blog/suffer-the-children/202005/vitamin-d-and-covid-19
Vitamin D and COVID-19
Can taking Vitamin D save your life?
Posted May 06, 2020
Until medical scientists discover an effective vaccine or treatment for COVID-19, prevention is the best defense. Medical scientists tell us that frequent hand washing, wearing a face mask when in public places, and social distancing are important preventive measures. A less discussed preventive measure, however, is the fact that having a robust Vitamin D level may play a significant role in preventing COVID-19. Recently, a string of studies have identified Vitamin D deficiency as a risk factor for the disease.
A recent report from the Philippines found that in patients infected with COVID-19, the patient’s level of Vitamin D was significantly associated with clinical outcomes. Vitamin D deficiency was associated with a higher level of death from the disease. And a new study by researchers at Queen Elizabeth Hospital Foundation Trust and the University of East Anglia in the UK prompted the authors to advise that vitamin D supplementation could protect against respiratory infections like COVID-19. Similarly, a recent study from Switzerland led researchers to “advise Vitamin D supplementation to protect against SARS-CoV2 infection.”
In early April 2020, I received an email about the COVID-19 epidemic from the renowned endocrinologist and former associate professor of medicine at UCLA, Sarfraz Zaidi, M.D.. Zaidi had previously cured me of an autoimmune disorder with large doses of vitamin D3, saving me from more invasive and Draconian cures. Zaidi had been talking with doctors in Iran, a country hard-hit by the COVID-19 epidemic. He wrote in his email: “Doctors from Iran who took care of severe cases of COVID-19 found most patients who died had vitamin D level of less than 50 ng/ml. It is no surprise to me. The optimal level of vitamin D — 25 OH Vitamin D — is between 50-100 ng/ml according to my own vast clinical experience…”
How does Vitamin D help fight respiratory infections like COVID-19? Zaidi explains: “Vitamin D stimulates the production of CAMP — Cathelicidin Anti-Microbial Peptide — from our own immune cells. Think of CAMP as our natural Anti-Viral agent.”
you have allready 76k death it will be 80k next week
if you dream of it will go ways just one thing, usa has the second most new cases of covid 19 in the world after russia
when a second wave comes it will looks even worse the 200k because many will say it not so deathly , i am immiune too it, ah it will go away soon, i am too young to get it
people will react different a secound time! some people who got it will watch out more for themself some will thing they cant get it a secont time
some people will be in fear soem will ignore it like it was not so bet i did got it last time
but the problem it some people who where immiune too it got sick a second time, not many but some and thets the problem
because it can be a genetic thing that only effects some people or the virus evolved in a way that it more like the pandemic flu and changes so fast that you antibodys does not recognize it the next time
Altair IV no wonder because the immiun sstem it the only thing that can fight corona illness for now
every thing that helps you getting a stronger immiun system will help you fight covid 19 if you get ill
@Para Noid For your eyes only. Melatonin Covid-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102583/
COVID-19: Melatonin as a potential adjuvant treatment
Rui Zhang, Xuebin Wang, […], and Russel J. Reiter
Additional article information
Abstract
This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology.
This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.
Keywords: COVID-19, SARS-CoV-2, Melatonin, Oxidation-reduction, Cytokines, Immunomodulation
Graphical abstract
Melatonin as a potential adjuvant treatment for COVID-19.
1. Introduction
Coronaviruses (CoVs) are RNA viruses infecting both human and animals; this infection involves the respiratory, gastrointestinal and central nervous system [1]. Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are infectious and lethal, and have caused thousands of deaths in the past two decades. The recent outbreak was discovered in Wuhan, China; this highly contagious disease has spread throughout China and other countries [2]. Although antiviral therapy, corticosteroid therapy and mechanical respiratory support have been applied, there is lack of a specific treatment for COVID-19 [2].
Melatonin (N-acetyl-5-methoxytryptamine) is a bioactive molecule with an array of health-promoting properties; melatonin has been successfully used to treat sleep disorders, delirium, atherosclerosis, respiratory disease and viral infections [3]. Previous research has documented the positive effects of melatonin in alleviating acute respiratory stress induced by virus, bacteria, radiation, etc. [[4], [5], [6]]. Herein, we review the evidence indicating that melatonin will have supportive adjuvant utility in treating COVID-19 induced pneumonia, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).
2. Pathogenesis of COVID-19 and the rationale for melatonin use
Patients with COVID-19 (who were infected by SARS-CoV-2) are reported to present with fever, dry cough, myalgia, fatigue, and diarrhea, etc. with symptoms varying somewhat with the patients’ age. In some cases, the severe progression of the disease results in ALI/ARDS, respiratory failure, heart failure, sepsis, and sudden cardiac arrest within a few days [2,7]. The pathogenic examination of lung specimens from mild COVID-19 patients (who were retrospectively found to have COVID-19 at the time of lung cancer surgery) showed edema, proteinaceous exudate with globules, patchy inflammatory cellular infiltration and moderate formation of hyaline membranes [8]. In a postmortem assessment of a COVID-19 patient with severe ARDS, specimens of infected lungs demonstrated bilateral diffuse alveolar damage with edema, pneumocyte desquamation and hyaline membrane formation [9].
Though these pathological reports were reported in only a small number of cases, the findings do resemble the pathological features found in SARS- and MERS-induced pneumonia [10]. SARS-CoVs, MERS-CoVs and SARS-CoV-2 are classified in beta-coronavirus family members [11]. Recent published research suggests that SARS-CoV-2 shares 79.0% nucleotide identity to SARS-CoV and 51.8% identity to MERS-CoV [12], indicating a high genetic homology among SARS-CoV-2, MERS-CoV and SARS-CoV. In SARS-CoV and MERS-CoV infected animal model, marked inflammatory and immune responses may activate a “cytokine storm”, and apoptosis of epithelial cells and endothelial cells; subsequently, vascular leakage, abnormal T cell and macrophages responses ensue and induce ALI/ARDS or even death [13].
Based on genetic homology and pathologic features of the infected lung, we predicted that a cytokine storm also prevails in patients with COVID-19. In the blood of patients with COVID-19, there was a marked increase in interleukin 1β (IL-1β), interferon γ (IFN-γ), interferon-inducible protein 10 (IP-10), and monocyte chemoattractant protein 1 (MCP-1), as well as IL-4 and IL-10 when compared to that of SARS patients. This suggests some potential difference from SARS and MERS in the pathogenesis of coronavirus [2]. There is also a potential repressed immune function in COVID-19 patients with the hypo-albuminemia, lymphopenia, neutropenia, and decreased percentage of CD8+ T cell [2,7]. Recent reports suggest that in some COVID-19 patients, although being negative for the viral nucleic acid test, still sometimes present with a high level of inflammation. A clinical trial using certolizumab pegol (a TNF blocker) along with other anti-virus therapies may have beneficial effects in COVID-19 patients. Collectively, the finding indicates that inflammation is a major feature in COVID-19 patients. Thus, we hypothesize that excessive inflammation, depressed immune system, and an activate cytokine storm substantially contribute to the pathogenesis of COVID-19.
In the early stages of coronaviruses infection, dendritic cells and epithelial cells are activated and express a cluster of pro-inflammatory cytokines and chemokines including IL-1β, IL-2, IL-6, IL-8, both IFN-α/β, tumor necrosis factor (TNF), C—C motif chemokine 3 (CCL3), CCL5, CCL2, and IP-10, etc. These are under the control of immune system. Thus, the overproduction of these cytokines and chemokines contributes to the development in disease [[14], [15], [16]].
IL-10, produced by T-helper-2 (Th2), is antiviral, with an infection of coronaviruses leading to a marked decrease in this agent [17,18].
Interestingly, COVID-19 patients sometimes have a significantly elevated level of IL-10 [2]. Whether this is a feature of the COVID-19 infection or the result of medical treatment is unknown. The amplification of the inflammatory response would promote cellular apoptosis or necrosis of the affected cells, which would further fuel inflammation, followed by increasing permeability of blood vessels and the aberrant accumulation of inflammatory monocytes, macrophages and neutrophils in the lung alveoli [19]. This vicious circle would intensify the situation as the regulation of immune response is lost and cytokine storm is further activated, resulting in dire consequences.
This putative “cytokine storm” pathology associated with coronaviruses is also supported by experimental SARS-CoV models, one of which showed that the severity of ALI was accompanied by an elevated expression of inflammation-related genes rather than increased viral titers. In another case, the ablation of IFN-α/β receptor or the depletion of inflammatory monocytes/macrophages caused a marked rise in the survival rate of coronaviruses host without a change in viral load [19,20]. Both situations suggest a potential amplifying mechanism involved in CoV-induced ALI/ARDS regardless of the viral load. If a similar pathology also exists in COVID-19, the attenuation of the cytokine storm by targeting several key steps in the process could bring about improved outcomes.
Melatonin is not viricidal but it has indirect anti-viral actions [3] due to its anti-inflammation, anti-oxidation and immune enhancing features [[21], [22], [23], [24]]. There are situations in which melatonin suppresses the features of viral infections. In mice whose central nervous system is infected by virus (e.g., encephalitis), the use of melatonin caused less viremia, reduced paralysis and death, and decreased virus load [25]. In previous respiratory syncytial virus models, melatonin caused down-regulation of acute lung oxidative injury, pro-inflammatory cytokine release and inflammatory cell recruitment. These findings, along with those recently summarized by Reiter et al. [3], support a rationale for melatonin use in viral diseases. Also, melatonin’s anti-inflammation, anti-oxidation, immune enhancing actions supports its potential attenuation of COVID-19 infection (Fig. 1 ).
America has always been violent. Our Nation has never hid from its belief and practice of privileging a few at the expense of the many. To be so wealthy 💰, we are morally bankrupt💔. Not new news, no, but it’s still infuriating and hurtful. Thanks for your reporting MSNBC. Though I remain hopeful, my doubt is best explained by this quote:
“Perhaps there has been, at some point in history, some great power whose elevation was exempt from the violent exploitation of other human bodies. If there has been, I have yet to discover it. But this banality of violence can never excuse America, because America makes no claim to the banal. America believes itself exceptional, the greatest and noblest nation ever to exist, a lone champion standing between the white city of democracy and the terrorists, despots, barbarians, and other enemies of civilization. One cannot, at once, claim to be superhuman and then plead mortal error. I propose to take our countrymen’s claims of American exceptionalism seriously, which is to say I propose subjecting our country to an exceptional moral standard. This is difficult because there exists, all around us, an apparatus urging us to accept American innocence at face value and not to inquire too much.” ✍🏽Ta-Nehisi Coates, Between the World and Me
Danley Danley you state the original inconvenient truth. Thanks for sharing.
HCQ studies. Please read and share. The left has blood on their hands. https://docs.google.com/document/d/1545C_dJWMIAgqeLEsfo2U8Kq5WprDuARXrJl6N1aDjY/edit
Well written and sourced Danley….from the outside, we see a rather fragile country full of false hope. Its ‘greatness’ comes from arrogance. Behind its thin veneer, there is very little soul.
Do keep yourself and your loved ones safe…
Republicans are destroying America, just like the last time a Republican was in Office, remember 911 and George W Bush, America cannot stand another Republican President.
@Billy Ray im goona start killing Republicans with the virus ha
@Domino Ryan they just red flaged u
They’re called humans, earthling, not republicans. On our planet, we call them the destroyers of the common grebulas, or on your planet, people.
what color is the paint your huffin?
Vote him out dude, its your only option.
You learn what a country is really made of when it has to deal with a crisis. And the US fails miserably for the whole world to watch live on TV. Republican mismanagement made the US an asocial country with no social infrastructure whatsoever. And the moron just repeated that he will get rid of Obamacare with no replacement. I mean we all know the Republicans replacement: well fare for the rich.
Michael Kahr what u must think of China? WHO? Or globalism at large! The EU? I think it’s going to fall apart. Live on tv and everything.
I know the wisdom of taxing people for not getting their healthcare is way better than anything capitalism could create.
@Toward Treatise I think China will come out on top from all this, but how knows, but I really can’t see the American Empire surviving this intacted
Hamish Gaffaney should we compare the EU and US? I think we r doing ok. Trump 2020 and we’re going to be just fine. China might even have to pay for this if people get angry enough.
“Conservatives say if you don’t give the rich more money, they will lose their incentive to invest. As for the poor, they tell us they’ve lost all incentive because we’ve given them too much money.” ~ George Carlin
Yes bill gates needs our money more. And polosi who somehow is worth millions from being a politition. How about some hcq studies to go along with flynns freedom https://docs.google.com/document/d/1545C_dJWMIAgqeLEsfo2U8Kq5WprDuARXrJl6N1aDjY/edit
Millions of Americans losing their jobs, and yet no one from this disaster of an administration has been fired.
They will retire soon, once their pockets are full of tax dollars
And they get flynn back so its plus 1
@Gabe Dudley flyn will get shot ha
@Domino Ryan seriously bro, seek help ! They red flagged you and your being monitored now.
@Jake the snake oh I’m scared I got conovirus what going to do punk
Only Rich and Privilege People can actually survive COVID-19.
The Government Bailed Out Insurance Companies, Big Banks, Car Manufacturers, Airlines, etc., but is not willing to Bail Out more than 43 million Renters.
#TrumpVirus #RepublicanPandemic
so much for being all that (‘the richest, most powerful nation in human history’). this pandemic has xposed the aggressive gutting o’ the country’s economy for the past 40 years. the cupboards really are bare – because when the workers are out working the landowners have been helping themselves to what they consider theirs. there is literally nothing shocking about witnessing what has been happening during the past roughly two months…
Enough about the Great Depression. This is the era of Trump. Let’s make it the Greatest Depression.
What Trump says about people dying, “it is what it is.” November 3rd. We have a newer smarter kinder president so Mr. Trump, Americans say, ” it is what it is.”
Whole World gets Early Christmas Present
Trump’s personal valet tests positive for coronavirus
I hope they shook hands and hugged.
Trump ” oops looks like we are gonna need to file for bankruptcy again. Mission Accomplished”
Not everyone, if many, have received the supposed “Stimulus Checks!”
Just wait until mortgage companies start foreclosing on everyone when people can’t pay.